St. Xavier's College

ST. XAVIER'S COLLEGE

THUMBA, THIRUVANANTHAPURAM

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shiny v

PG Department of Physics

Dr. Shyni V.

Assistant Professor

shynivijin18sxc@gmail.com8606811068

Profile Summary

Dr. Shyni V. is a highly motivated Assistant Professor with a Ph.D. in Physics, specialising in Spectroscopy and Drug Design, supported by two years of teaching experience and a strong publication record in international peer-reviewed journals. Her expertise spans molecular spectroscopy, DFT calculations, molecular docking, computational chemistry, nanomaterials, and structural characterisation techniques, with a particular research focus on the anticancer and antiproliferative potential of drug molecules adsorbed on gold nanoparticles, examined through combined SERS, in silico, and in vitro approaches.

Her research has been published extensively in journals such as the Journal of Molecular Structure and the Journal of Molecular Recognition, and presented at numerous national and international conferences, including multiple editions of the International Conference on Perspectives in Vibrational Spectroscopy. Combining rigorous computational and experimental expertise with a strong commitment to curriculum delivery, student mentoring, and research supervision, Dr. Shyni brings a well-rounded academic profile geared towards teaching excellence and impactful scientific contribution in higher education.

Experience

2 years

Specialization

Spectroscopy in drug designing

Qualifications

MSc,M.Phil,MEd,PhD

Seminars & Workshops

  • Shyni V, et al. Potential inhibition of DPHA molecule on lung cancer cell line. Presented at the 8th International Conference on Perspectives in Vibrational Spectroscopy (ICOPVS-2020).
  • Shyni V, et al. A DFT Approach to the Surface-Enhanced Raman Scattering of 2,4-benzothiadiazine-7-sulfonamide Adsorbed on Gold Nanoparticles. Presented at the International Conference on Novel Materials for Evolving Technological Applications (ICNM2020), 2 March 2020.
  • Shyni V, et al. Studies on absorption of 2-amino-2-methylpropan1-ol; 3-dimethyl-7H-purine-2,6-dione on gold nanoparticles by SERS and DFT calculations. Presented at the 8th International Conference on Perspectives in Vibrational Spectroscopy (ICOPVS2020), 24–28 February 2020.
  • Shyni V, et al. Identification of binding sites of D-isosorbide in lung cancer cells using SERS imaging and molecular docking. Presented at the 7th International Conference on Perspectives in Vibrational Spectroscopy (ICOPVS-2018).
  • Shyni V, et al. Identification of binding sites of D-isosorbide in lung cancer cells using SERS imaging and molecular docking. Presented at the 7th International Conference on Perspectives in Vibrational Spectroscopy (ICOPVS-2018), 25–29 November 2018.
  • Shyni V, et al. Investigation of the binding sites and orientation of 4-chloro-N-(2-methylindolin-1-yl)-3-sulfamoylbenzamide by Surface-Enhanced Raman Scattering and molecular docking. Presented at the National Conference on Recent Advances in Spectroscopy of Advanced Materials (NCRSM-2018), 25–26 September 2018.
  • Shyni V, et al. Structure, vibrational investigation and DFT calculation of N-(2-(2-(1H-indole-2-carbonyl)hydrazinyl)-2oxoacetyl)-4-chlorophenyl)acetamide. Presented at the National Conference on Technologically Advanced Materials.
  • Shyni V, et al. Molecular docking and vibrational spectral studies of the diuretic drug D-isosorbide. Presented at the International Conference on Spectroscopy of Biomolecules and Advanced Materials.

Research and Publications

  • Shyni V, et al. (2022). Vibrational spectra and molecular docking studies of bergapten isolated from Melicope denhamii leaves as anti-breast cancer agents. Journal of Molecular Structure. https://doi.org/10.1016/j.molstruc.2022.132656
  • Shyni V, et al. (2021). Investigations of dianhydro-D-glucitol adsorbed on AuNPs surface: In silico and in vitro approach based on anticancer activity studies against A549 lung cancer cell lines. Journal of Molecular Recognition. https://doi.org/10.1002/jmr.2899
  • Shyni V, et al. (2021). Spectroscopic, density functional theoretical study, molecular docking, and in vitro studies based on anticancer activity against A549 lung cancer cell line of diphenylhydantoin adsorbed on AuNPs surface. Journal of Molecular Recognition. https://doi.org/10.1002/jmr.2916
  • Shyni V, et al. (2021). Anticancer activity of indapamide adsorbed on gold nanoparticles: DFT, in silico, and in vitro analysis. Journal of Molecular Recognition. https://doi.org/10.1002/jmr.2920
  • Shyni V, et al. (2021). Spectroscopic studies, quantum chemical investigations, and in silico and in vitro scrutiny of the diuretic drug trichlormethiazide adsorbed on AuNPs. Journal of Molecular Recognition. https://doi.org/10.1002/jmr.2939
  • Shyni V, et al. Synthesis, crystal structure, vibrational profiling, DFT studies and molecular docking of N-(4-chloro-2-{2-(1H-indol2-ylcarbonyl)hydrazinylacetyl}phenyl)acetamide·DMSO: A new antiproliferative agent. Journal of Molecular Structure.
  • Shyni V, et al. Molecular structure investigation, charge transfer interactions, Hirshfeld surface analysis and molecular docking of 2′-(4-bromobenzoyl)-1′-(2-chlorophenyl)-1,1′,2,2′,5′,6′,7′,7a′octahydro-spiro[indole-3,3′-pyrrolizin]-2-one using quantum chemical computations. International Journal of Advanced Science and Technology.
  • Shyni V, et al. Density functional theoretical study, molecular docking, and in vitro anticancer activity studies of the potent diuretic drug spironolactone adsorbed on AuNPs surface against A549 lung cancer cells. Colloids and Surfaces A: Physicochemical and Engineering Aspects.